3-D used to study prostate cancer spread

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BRISBANE, Queensland Australia

(UPI) — Australian scientists say they

are studying the spread of

prostate cancer to the bones

using a three-dimensional model

of tissue-engineered bone.

Shirly Sieh, a doctoral student at the Queensland University

of Technology’s Institute of Health and Biomedical Innovation

said she is studying the way cancer cells escape from the

prostate through the bloodstream to form tumor colonies,

most often in the spine and long bones.

“It is an innovative study which uses a tissue engineering

platform technology developed by IHBI’s Professor

Dietmar Hutmacher

in order to investigate the interaction between bones

and cancer cells,” Sieh said. “Tissue-engineered bone

provides the 3D architecture for the cancer cells (that)

more closely resemble bone metastasis instead of growing

the cancer cells and bone cells on a flat Petrie dish.”

She said it is still not clear how bones and cancer cells interact,

so she is growing prostate cancer cells on the tissue-engineered

bone to observe those interactions.

Sieh said scientists want to understand why prostate cancer cells

are attracted to bone sites.

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She and doctoral student Amy Lubik,

who is supervised by

Professor Colleen Nelson,

are also studying the effect

the cancer cells in the bones

have on male hormone production,

particularly on the hormone androgen.

Copyright 2009 by United Press International
Sourced and published by Henry Sapiecha 9th May 2009


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