COMPUTER BIO LOGIC GATES FROM BACTERIA

DNA is often referred to as the building block of life. Now scientists from Imperial College London have demonstrated that DNA (and bacteria) can be used to create the fundamental building blocks of a computer – logic gates. Using DNA and harmless gut bacteria, the scientists have built what they claim are the most advanced biological logic gates ever created by scientists. The research could lead to the development of a new generation of microscopic biological computing devices that, amongst other things, could travel around the body cleaning arteries and destroying cancers.

While previous research had already proven biological logic gates could be made, the Imperial College scientists say the big advantage of their creations is that they behave like their electronic counterparts – replicating the way that electronic logic gates process information by either switching “on” or “off.” Importantly, the new biological logic gates are also modular, meaning they could be fitted together to make different types of logic gates and more complex biological processors.

To create a type of logic gate called an “AND gate,” the team used modified DNA to reprogram Escherichia Coli (E.Coli) bacteria to perform the same switching on and off process as its electronic equivalent when stimulated by chemicals. In a similar way to the way electronic components are made, the team demonstrated that the biological gates could be connected together to form more complex components.

The team also created a “NOT gate” and combined it with the AND gate to produce the more complex “NAND gate.” NAND gates are significant because any Boolean function (AND, OR, NOT, XOR, XNOR), which play a basic role in the design of computer chips, can be implemented by using a combination of NAND gates.

The researchers will now try and develop more complex circuitry that comprises multiple logic gates. To accomplish this they will need to find a way to link multiple biological logic gates together that is similar to the way in which electronic logic gates are linked together to enable complex processing to be carried out.

“We believe that the next stage of our research could lead to a totally new type of circuitry for processing information,” said Professor Martin Buck from the Department of Life Sciences at Imperial College London. “In the future, we may see complex biological circuitry processing information using chemicals, much in the same way that our body uses them to process and store information.”

The team also suggests that these biological logic gates could one day form the building blocks of microscopic biological devices, such as sensors that swim inside arteries, detecting the build up of harmful plaque and rapidly delivering medications to the affected area. Other sensors could detect and destroy cancer cells inside the body, while others could be deployed in the environment to monitor pollution and detect and neutralize dangerous toxins.

Sourced & published by Henry Sapiecha

We all know about these commonly used inventions, but they had a dark side.

1…..Ecstasy


Anton Köllisch developed 3,4-methylenedioxymethamphetamine as a by-product of research for a drug combating abnormal bleeding. It was largely ignored for around 70 years until it became popular in  dance clubs of the early 80s. It was only when the Rave party culture of the late 80s adopted Ecstasy as its drug of choice that MDMA became one of the top four illegal drugs in use killing an estimated 50 people a year in the UK alone. Its inventor died in World War I.

2…Concentration camps

Frederick Roberts, 1st Earl Roberts set up “safe refugee camps” to provide refuge for civilian families who had been forced to abandon their homes for one  reason or another related to the Boer War. However, when Lord Kitchener succeeded Roberts as commander-in-chief in South Africa in 1900, the British Army introduced new tactics in an attempt to break the guerrilla campaign and the influx of civilians grew dramatically as a result. Kitchener initiated plans to- “flush out guerrillas in a series of systematic drives, organized like a sporting shoot, with success defined in a weekly ‘bag’ of killed, captured and wounded, and to sweep the country bare of everything that could give sustenance to the guerrillas, including women and children.” Of the 28,000 Boer men captured as prisoners of war, 25,630 were sent overseas. The vast majority of Boers remaining in the local camps were women and children. Over 26,000 women and children were to perish in these concentration camps.

3…ROCKETS


Despite a lifelong passion for astronomy and a dream that rockets could be used to explore space, Wernher von Braun’s talents were used to produce the Nazi V2 rocket which killed 7,250 military personnel and civilians and an estimated 20,000 slave laborers during construction. Later in the US he developed a series of ICBM rockets capable of transporting multiple nuclear warheads around the globe before redeeming his reputation with the Saturn V rocket that put men on the moon

4…NUCLEAR FUSION

Sir Marcus Laurence Elwin Oliphant was the first to discover that heavy hydrogen nuclei could be made to react with each other . This fusion reaction is the basis of a hydrogen bomb. Ten years later, American scientist Edward Teller would press to use Oliphant’s discovery in order to build the hydrogen bomb. However, Oliphant did not foresee this – “We had no idea whatever that this fusion reaction would one day be applied to make hydrogen bombs. Our curiosity was just curiosity about the structure of the nucleus of the atom”.

5…SARIN GAS

Dr. Gerhard Schrader was a German chemist specializing in the discovery of new insecticides, hoping to make progress in the fight against world hunger. However, Dr. Schrader is best known for his accidental discovery of nerve agents such as sarin and tabun, and for this he is sometimes called the “father of the nerve agents”.

6…LEADED PETROL


Thomas Midgley discovered the CFC Freon as a safe refrigerant to replace the highly toxic refrigerants such as ammonia in common use. This resulted in extensive damage to the Ozone Layer. His other famous idea was to add tetraethyl lead to gasoline to prevent “knocking” thus causing worldwide health issues and deaths from lead poisoning. He is considered to be the man that – “had more impact on the atmosphere than any other single organism in Earth’s history.”

7…TNT

Joseph Wilbrand was a German chemist who discovered trinitrotoluene in 1863 to be used as a yellow dye. It wasn’t until after 1902 that the devastating power of TNT as it is better known was fully realized and it was utilized as an explosive in time for extensive use by both sides in World War I, World War II. It is still in military & industrial use today.

8…GATLING GUNAdd an Image


Richard Jordan Gatling invented the Gatling gun after he noticed the majority of dead from the American Civil War died from infection & illness, rather than gunshots. In 1877, he wrote: “It occurred to me that if I could invent a machine – a gun – which could by its rapidity of fire, enable one man to do as much battle duty as a hundred, that it would, to a large extent supersede the necessity of large armies, and consequently, exposure to battle and disease would be greatly diminished.” The Gatling gun was used most successfully to expand European colonial empires by ruthlessly mowing down native tribesmen armed with basic primitive weapons.

9…AGENT ORANGE

Arthur Galston developed a chemical that was meant to speed the growth of soybeans and allow them to be grown in areas with a short season. Unfortunately in high concentrations it would defoliate them and it was made into a herbicide even though Galston had grave concerns about its effects on humans. It was supplied to the US government in orange striped barrels and 77 million litres of Agent Orange were sprayed on Vietnam causing 400000 deaths and disabilities with another 500000 birth defects. Service personnel to some extent were also affected

10…ZYKLON B

Fritz Haber was a Nobel Prize winning Jewish scientist who created cheap nitrogen fertilizer and also made chemical weapons for the German side in World War I. It was his creation of an insecticide mainly used as a fumigant in grain stores that was responsible for the deaths of an estimated 1.2 million people. His Zyklon B became the nazis preferred method of execution in gas chambers during the Holocaust.

Sourced & published by Henry Sapiecha